Skip to Content
Merck

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

Synonyms:
APO2L, Apo-2L, CD253, TL2, TRAIL
Species:
Human TNFSF10 (8743), Mouse Tnfsf10 (22035), Rat Tnfsf10 (246775), Zebrafish tnfsf10 (436866), domestic cat TNFSF10 (100174789), domestic cat TNFSF10 (101083289), dog TNFSF10 (100174780), chicken TNFSF10 (378894), cow TNFSF10 (507215), sheep TNFSF10 (101114153) ...More
UniProtKB ID:
P50591, A1Y9B3
Gene ID:
  • Human(8743) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(22035) tumor necrosis factor (ligand) superfamily, member 10
  • Rat(246775) tumor necrosis factor (ligand) superfamily, member 10
  • Zebrafish(436866) tumor necrosis factor (ligand) superfamily, member 10
  • domestic cat(100174789) tumor necrosis factor (ligand) superfamily, member 10
  • domestic cat(101083289) tumor necrosis factor (ligand) superfamily, member 10
  • dog(100174780) tumor necrosis factor (ligand) superfamily, member 10
  • chicken(378894) tumor necrosis factor (ligand) superfamily, member 10
  • cow(507215) tumor necrosis factor (ligand) superfamily, member 10
  • sheep(101114153) tumor necrosis factor (ligand) superfamily, member 10
  • domestic guinea pig(100734497) tumor necrosis factor (ligand) superfamily, member 10
  • naked mole-rat(101702439) tumor necrosis factor (ligand) superfamily, member 10

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
T3067
Monoclonal Anti-TRAIL antibody produced in mouse, clone 75411, purified immunoglobulin, lyophilized powder,
Species Reactivity
human
Application
immunohistochemistry
neutralization
SAB3500424
Anti-Trail antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
CWA-1122
Anti-Human CD253/TRAIL (2E5) ColorWheel® Dye-Ready mAb, for use with ColorWheel® Dyes (Required, (Sold Separately)),
Species Reactivity
human
Application
flow cytometry

Proteins

Product Number
Description
Species
T5694
TRAIL human, recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder,
Species
human
GF092
TRAIL Protein, Recombinant human, Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.,
Species
human
SRP8024
TRAIL, Soluble human, recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE),
Species
human
T9701
TRAIL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder,
Species
human
SRP3237
TRAIL from mouse, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
mouse