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Merck

SOCS3

suppressor of cytokine signaling 3

Synonyms:
ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
Species:
Human SOCS3 (9021), Mouse Socs3 (12702), Rat Socs3 (89829), chicken SOCS3 (395299), Horse SOCS3 (100050730), domestic cat SOCS3 (101081846), dog SOCS3 (442949), cow SOCS3 (282081), sheep SOCS3 (100294595), domestic guinea pig Socs3 (100725088)
UniProtKB ID:
O14543, O14509
Gene ID:
  • Human(9021) Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
  • Mouse(12702) suppressor of cytokine signaling 3
  • Rat(89829) suppressor of cytokine signaling 3
  • chicken(395299) suppressor of cytokine signaling 3
  • Horse(100050730) suppressor of cytokine signaling 3
  • domestic cat(101081846) suppressor of cytokine signaling 3
  • dog(442949) suppressor of cytokine signaling 3
  • cow(282081) suppressor of cytokine signaling 3
  • sheep(100294595) suppressor of cytokine signaling 3
  • domestic guinea pig(100725088) suppressor of cytokine signaling 3
  • naked mole-rat(101704157) suppressor of cytokine signaling 3

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1409970
Anti-SOCS3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
04-004
Anti-SOCS3 Antibody, clone 1B2, clone 1B2, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
western blot