SMAD4
SMAD family member 4
Synonyms:
DPC4, JIP, MADH4, MYHRS
Species:
Human SMAD4 (4089), Mouse Smad4 (17128), Rat Smad4 (50554), Zebrafish smad4 (30640), Horse SMAD4 (100033846), domestic cat SMAD4 (101093650), dog SMAD4 (476196), naked mole-rat Smad4 (101703764), domestic guinea pig Smad4 (100717853), cow SMAD4 (540248) ...More
UniProtKB ID:
Gene ID:
- Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
- Mouse(17128) SMAD family member 4
- Rat(50554) SMAD family member 4
- Zebrafish(30640) MAD homolog 4 (Drosophila)
- Horse(100033846) SMAD family member 4
- domestic cat(101093650) SMAD family member 4
- dog(476196) SMAD family member 4
- naked mole-rat(101703764) SMAD family member 4
- domestic guinea pig(100717853) SMAD family member 4
- cow(540248) SMAD family member 4
- sheep(443171) SMAD family member 4
- Goat(100861019) SMAD family member 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 3E2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
proximity ligation assay
western blot
immunofluorescence
proximity ligation assay
western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 4G1C6, ascites fluid,
Species Reactivity
human
Application
ELISA
flow cytometry
immunofluorescence
immunohistochemistry
western blot
flow cytometry
immunofluorescence
immunohistochemistry
western blot
Anti-SMAD4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot
western blot
ANTI-SMAD4 antibody produced in mouse, clone 4C6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
ANTI-SMAD4 antibody produced in mouse, clone 3D7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Proteins
Product Number
Description
Species
SMAD4, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human