SLC52A2
solute carrier family 52 (riboflavin transporter), member 2
Synonyms:
BVVLS2, D15Ertd747e, GPCR41, GPR172A, PAR1, RFT3, RFVT2, hRFT3
Species:
Human SLC52A2 (79581), Mouse Slc52a2 (52710), Rat Slc52a2 (362942), Zebrafish slc52a2 (323832), sheep SLC52A2 (101117771), naked mole-rat Slc52a2 (101721412), domestic guinea pig Slc52a2 (100734411)
UniProtKB ID:
Gene ID:
- Human(79581) Summary: This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012]
- Mouse(52710) solute carrier protein 52, member 2
- Rat(362942) solute carrier family 52, riboflavin transporter, member 2
- Zebrafish(323832) solute carrier family 52, riboflavin transporter, member 2
- sheep(101117771) solute carrier family 52, riboflavin transporter, member 2
- naked mole-rat(101721412) solute carrier family 52, riboflavin transporter, member 2
- domestic guinea pig(100734411) solute carrier family 52, riboflavin transporter, member 2
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