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Merck

SLC12A3

solute carrier family 12 (sodium/chloride transporter), member 3

Synonyms:
NCC, NCCT, TSC
Species:
UniProtKB ID:
Gene ID:
  • Human(6559) Summary: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(20497) solute carrier family 12, member 3
  • Rat(54300) solute carrier family 12 (sodium/chloride transporter), member 3
  • domestic guinea pig(100726300) solute carrier family 12 (sodium/chloride transporters), member 3
  • naked mole-rat(101704301) solute carrier family 12 (sodium/chloride transporters), member 3
  • cow(404171) solute carrier family 12 (sodium/chloride transporters), member 3
  • sheep(101120940) solute carrier family 12 (sodium/chloride transporters), member 3
  • Zebrafish(565439) solute carrier family 12 (sodium/chloride transporters), member 3
  • Horse(100051953) solute carrier family 12 (sodium/chloride transporters), member 3
  • domestic cat(101082284) solute carrier family 12 (sodium/chloride transporters), member 3
  • dog(478118) solute carrier family 12 (sodium/chloride transporters), member 3
  • chicken(415692) solute carrier family 12 (sodium/chloride transporters), member 3

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SLC12A3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-SLC12A3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Benzthiazide, ,
Species
human
Chlortalidone for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Chlorothiazide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Chlorthalidone, European Pharmacopoeia (EP) Reference Standard,
Species
human