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Merck

SHC1

SHC (Src homology 2 domain containing) transforming protein 1

Synonyms:
SHC, SHCA
Species:
Human SHC1 (6464), Mouse Shc1 (20416), Rat Shc1 (85385), Zebrafish shc1 (323818), dog SHC1 (490439), Horse SHC1 (100063053), domestic cat SHC1 (101092911), chicken SHC1 (395934), cow SHC1 (507196), sheep SHC1 (101113548) ...More
UniProtKB ID:
P29353, B5BU19, D3DV78, O15290, Q5T180, Q5T183, Q5T184, Q5T185
Gene ID:
  • Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
  • Mouse(20416) src homology 2 domain-containing transforming protein C1
  • Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
  • Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
  • dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
  • Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
  • domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
  • chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1
  • cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
  • sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
  • naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
  • domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4502769
Anti-SHC antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4300245
Anti-phospho-SHC1 (pTyr349) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot
AV50490
Anti-SHC1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
MABS2309
Anti-p66shc Antibody, clone BG8, ,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunofluorescence
western blot