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Merck

RBPJ

recombination signal binding protein for immunoglobulin kappa J region

Synonyms:
AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl
Species:
Human RBPJ (3516), Mouse Rbpj (19664), Rat Rbpj (679028), chicken RBPJ (422802), Horse RBPJ (100055547), domestic cat RBPJ (101100207), dog RBPJ (479122), domestic guinea pig Rbpj (100716535), naked mole-rat Rbpj (101726624), cow RBPJ (767928)
UniProtKB ID:
Q06330, B4DY22, Q5XKH9, Q6P1N3
Gene ID:
  • Human(3516) Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2011]
  • Mouse(19664) recombination signal binding protein for immunoglobulin kappa J region
  • Rat(679028) recombination signal binding protein for immunoglobulin kappa J region
  • chicken(422802) recombination signal binding protein for immunoglobulin kappa J region
  • Horse(100055547) recombination signal binding protein for immunoglobulin kappa J region
  • domestic cat(101100207) recombination signal binding protein for immunoglobulin kappa J region
  • dog(479122) recombination signal binding protein for immunoglobulin kappa J region
  • domestic guinea pig(100716535) recombination signal binding protein for immunoglobulin kappa J region
  • naked mole-rat(101726624) recombination signal binding protein for immunoglobulin kappa J region
  • cow(767928) recombination signal binding protein for immunoglobulin kappa J region
  • sheep(101107196) recombination signal binding protein for immunoglobulin kappa J region

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Antibodies

Product Number
Description
Species Reactivity
Application
AV31121
Anti-RBPJ antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot