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Merck

PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Synonyms:
COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Species:
UniProtKB ID:
Gene ID:
  • Human(5742) Summary: This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
  • Mouse(19224) prostaglandin-endoperoxide synthase 1
  • Rat(24693) prostaglandin-endoperoxide synthase 1
  • Zebrafish(246226) prostaglandin-endoperoxide synthase 1
  • dog(403544) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • Horse(100034087) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic cat(101092557) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • chicken(427752) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • domestic guinea pig(100714030) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • naked mole-rat(101698854) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • cow(282022) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
  • sheep(443551) prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PTGS1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rat, sheep
Application
immunohistochemistry
western blot
Anti-COX1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Phenazone, European Pharmacopoeia (EP) Reference Standard,
Species
human
Antipyrine, tested according to Ph. Eur.,
Species
human
Antipyrine, analytical standard,
Species
human
Niflumic acid, ,
Species
human
Dipyron monohydrate, VETRANAL®, analytical standard,
Species
human