PRKCG
protein kinase C, gamma
Synonyms:
PKC-gamma, PKCC, PKCG, SCA14
Species:
Human PRKCG (5582), Mouse Prkcg (18752), Rat Prkcg (24681), Zebrafish prkcg (100003514), dog PRKCG (484316), Horse PRKCG (100062549), domestic cat PRKCG (101082196), domestic guinea pig Prkcg (100733947), Domestic Rabbit PRKCG (100009102), naked mole-rat Prkcg (101698346) ...More
UniProtKB ID:
Gene ID:
- Human(5582) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
- Mouse(18752) protein kinase C, gamma
- Rat(24681) protein kinase C, gamma
- Zebrafish(100003514) protein kinase C, gamma
- dog(484316) protein kinase C, gamma
- Horse(100062549) protein kinase C, gamma
- domestic cat(101082196) protein kinase C, gamma
- domestic guinea pig(100733947) protein kinase C, gamma
- Domestic Rabbit(100009102) protein kinase C, gamma
- naked mole-rat(101698346) protein kinase C, gamma
- cow(282002) protein kinase C, gamma
- sheep(101116423) protein kinase C, gamma
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Protein Kinase C (PKC) antibody produced in mouse, clone MC5, ascites fluid,
Species Reactivity
bovine, human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Anti-phospho-PKC-pan (pThr497) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PKCγ, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human