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Merck

PAK4

p21 protein (Cdc42/Rac)-activated kinase 4

Synonyms:
Species:
Human PAK4 (10298), Mouse Pak4 (70584), Rat Pak4 (292756), domestic guinea pig Pak4 (100736193), naked mole-rat Pak4 (101720492), Domestic Rabbit PAK4 (100341934), sheep PAK4 (101115152), Zebrafish pak4 (431769), chicken PAK4 (770462), cow PAK4 (539742) ...More
UniProtKB ID:
O96013, B4DGG6, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
Gene ID:
  • Human(10298) Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(70584) p21 protein (Cdc42/Rac)-activated kinase 4
  • Rat(292756) p21 protein (Cdc42/Rac)-activated kinase 4
  • domestic guinea pig(100736193) p21 protein (Cdc42/Rac)-activated kinase 4
  • naked mole-rat(101720492) p21 protein (Cdc42/Rac)-activated kinase 4
  • Domestic Rabbit(100341934) p21 protein (Cdc42/Rac)-activated kinase 4
  • sheep(101115152) p21 protein (Cdc42/Rac)-activated kinase 4
  • Zebrafish(431769) p21 protein (Cdc42/Rac)-activated kinase 4
  • chicken(770462) p21 protein (Cdc42/Rac)-activated kinase 4
  • cow(539742) p21 protein (Cdc42/Rac)-activated kinase 4
  • Horse(100067000) p21 protein (Cdc42/Rac)-activated kinase 4
  • domestic cat(101098348) p21 protein (Cdc42/Rac)-activated kinase 4
  • dog(484513) p21 protein (Cdc42/Rac)-activated kinase 4

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0010298M1
Monoclonal Anti-PAK4 antibody produced in mouse, clone 3F10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
SAB4504052
Anti-phospho-PAK4/5/6 (pSer474) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

Proteins

Product Number
Description
Species
K3143
PAK4, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human