Skip to Content
Merck

NR0B2

nuclear receptor subfamily 0, group B, member 2

Synonyms:
SHP, SHP1
Species:
Human NR0B2 (8431), Mouse Nr0b2 (23957), Rat Nr0b2 (117274), chicken NR0B2 (768353), domestic cat NR0B2 (101081062), cow NR0B2 (514770), dog NR0B2 (612125), domestic guinea pig Nr0b2 (100726296), naked mole-rat Nr0b2 (101720554), sheep NR0B2 (101114500)
UniProtKB ID:
Q15466, Q5QP36
Gene ID:
  • Human(8431) Summary: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
  • Mouse(23957) nuclear receptor subfamily 0, group B, member 2
  • Rat(117274) nuclear receptor subfamily 0, group B, member 2
  • chicken(768353) nuclear receptor subfamily 0, group B, member 2
  • domestic cat(101081062) nuclear receptor subfamily 0, group B, member 2
  • cow(514770) nuclear receptor subfamily 0, group B, member 2
  • dog(612125) nuclear receptor subfamily 0, group B, member 2
  • domestic guinea pig(100726296) nuclear receptor subfamily 0, group B, member 2
  • naked mole-rat(101720554) nuclear receptor subfamily 0, group B, member 2
  • sheep(101114500) nuclear receptor subfamily 0, group B, member 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
WH0008431M1
Monoclonal Anti-NR0B2 antibody produced in mouse, clone 1A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
SAB2101631
Anti-NR0B2 (ab4) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, human, rabbit
Application
immunohistochemistry
western blot