NOTCH4
notch 4
Synonyms:
INT3, NOTCH3
Species:
Human NOTCH4 (4855), Mouse Notch4 (18132), Rat Notch4 (406162), naked mole-rat Notch4 (101708407), Domestic Rabbit NOTCH4 (100343400), domestic guinea pig Notch4 (100712850), sheep NOTCH4 (101111324), domestic cat NOTCH4 (101080381), Horse NOTCH4 (100059541), dog NOTCH4 (481726)
UniProtKB ID:
Gene ID:
- Human(4855) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(18132) notch 4
- Rat(406162) notch 4
- naked mole-rat(101708407) notch 4
- Domestic Rabbit(100343400) notch 4
- domestic guinea pig(100712850) notch 4
- sheep(101111324) notch 4
- domestic cat(101080381) notch 4
- Horse(100059541) notch 4
- dog(481726) notch 4
- cow(536128) notch 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NOTCH4 (Cleaved-Val1432), C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-NOTCH4 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot