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Merck

NOD1

nucleotide-binding oligomerization domain containing 1

Synonyms:
CARD4, CLR7.1, NLRC1
Species:
Human NOD1 (10392), Mouse Nod1 (107607), Rat Nod1 (500133), Zebrafish nod1 (100330810), Horse NOD1 (100069844), cow NOD1 (781426), domestic cat NOD1 (101086963), chicken NOD1 (420677), dog NOD1 (482382), sheep NOD1 (101102721) ...More
UniProtKB ID:
Q9Y239, Q549U4, Q8IWF5
Gene ID:
  • Human(10392) Summary: This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]
  • Mouse(107607) nucleotide-binding oligomerization domain containing 1
  • Rat(500133) nucleotide-binding oligomerization domain containing 1
  • Zebrafish(100330810) nucleotide-binding oligomerization domain containing 1
  • Horse(100069844) nucleotide-binding oligomerization domain containing 1
  • cow(781426) nucleotide-binding oligomerization domain containing 1
  • domestic cat(101086963) nucleotide-binding oligomerization domain containing 1
  • chicken(420677) nucleotide-binding oligomerization domain containing 1
  • dog(482382) nucleotide-binding oligomerization domain containing 1
  • sheep(101102721) nucleotide-binding oligomerization domain containing 1
  • naked mole-rat(101724724) nucleotide-binding oligomerization domain containing 1
  • Domestic Rabbit(100345423) nucleotide-binding oligomerization domain containing 1
  • domestic guinea pig(100722894) nucleotide-binding oligomerization domain containing 1

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