MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Synonyms:
ACTFS, HDMX, hdm2
Species:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...More
UniProtKB ID:
Gene ID:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-MDM2 antibody produced in mouse, clone 1A7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Anti-phospho-MDM2 (pSer186+Ser188) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunofluorescence
Monoclonal Anti-MDM2 antibody produced in mouse, ~2 mg/mL, clone MD-219, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
flow cytometry
immunocytochemistry
microarray
western blot
flow cytometry
immunocytochemistry
microarray
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Species Reactivity
human
Application
Anti-MDM2 (Ab-6) Mouse mAb (5B10C), liquid, clone 5B10C, Calbiochem®,
Species Reactivity
human
Application