Skip to Content
Merck

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

Synonyms:
FLH21957, HGK, MEKKK4, NIK
Species:
Human MAP4K4 (9448), Mouse Map4k4 (26921), Rat Map4k4 (301363), chicken MAP4K4 (418714), cow MAP4K4 (509109), domestic cat MAP4K4 (101081214), dog MAP4K4 (481331), naked mole-rat Map4k4 (101707800), domestic guinea pig Map4k4 (100723651), sheep MAP4K4 (101109789)
UniProtKB ID:
O95819, O75172, Q9NST7
Gene ID:
  • Human(9448) Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(26921) mitogen-activated protein kinase kinase kinase kinase 4
  • Rat(301363) mitogen-activated protein kinase kinase kinase kinase 4
  • chicken(418714) mitogen-activated protein kinase kinase kinase kinase 4
  • cow(509109) mitogen-activated protein kinase kinase kinase kinase 4
  • domestic cat(101081214) mitogen-activated protein kinase kinase kinase kinase 4
  • dog(481331) mitogen-activated protein kinase kinase kinase kinase 4
  • naked mole-rat(101707800) mitogen-activated protein kinase kinase kinase kinase 4
  • domestic guinea pig(100723651) mitogen-activated protein kinase kinase kinase kinase 4
  • sheep(101109789) mitogen-activated protein kinase kinase kinase kinase 4

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
ST1641
Anti-MAP4K4 Mouse mAb (4A5), liquid, clone 4A5, Calbiochem®,
Species Reactivity
human
Application