MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Synonyms:
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
Species:
Human MAP3K1 (4214), Mouse Map3k1 (26401), Rat Map3k1 (116667), sheep MAP3K1 (101112260), domestic guinea pig Map3k1 (100723456), naked mole-rat Map3k1 (101720769), Domestic Rabbit MAP3K1 (100328655), Zebrafish map3k1 (100334486), chicken MAP3K1 (427144), cow MAP3K1 (523962) ...More
UniProtKB ID:
Gene ID:
- Human(4214) Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
- Mouse(26401) mitogen-activated protein kinase kinase kinase 1
- Rat(116667) mitogen activated protein kinase kinase kinase 1
- sheep(101112260) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- domestic guinea pig(100723456) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- naked mole-rat(101720769) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- Domestic Rabbit(100328655) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- Zebrafish(100334486) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- chicken(427144) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- cow(523962) mitogen-activated protein kinase kinase kinase 1
- Horse(100061688) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- domestic cat(101090328) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- dog(478061) mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MAP3K1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Monoclonal Anti-MAP3K1 antibody produced in mouse, clone 2F6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Anti-phospho-MAP3K1 (pThr1402) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
MEKK1 (664-1512), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human