MAN1B1
mannosidase, alpha, class 1B, member 1
Synonyms:
ERMAN1, MANA-ER, MRT15
Species:
Human MAN1B1 (11253), Mouse Man1b1 (227619), Rat Man1b1 (499751), domestic guinea pig Man1b1 (100715996), naked mole-rat Man1b1 (101724891), Zebrafish man1b1 (556237), cow MAN1B1 (100336900), Horse MAN1B1 (100147680), dog MAN1B1 (480667), chicken MAN1B1 (417296)
UniProtKB ID:
Gene ID:
- Human(11253) Summary: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
- Mouse(227619) mannosidase, alpha, class 1B, member 1
- Rat(499751) mannosidase, alpha, class 1B, member 1
- domestic guinea pig(100715996) mannosidase, alpha, class 1B, member 1
- naked mole-rat(101724891) mannosidase, alpha, class 1B, member 1
- Zebrafish(556237) mannosidase, alpha, class 1B, member 1
- cow(100336900) mannosidase, alpha, class 1B, member 1
- Horse(100147680) mannosidase, alpha, class 1B, member 1
- dog(480667) mannosidase, alpha, class 1B, member 1
- chicken(417296) mannosidase, alpha, class 1B, member 1
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