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Merck

KRIT1

KRIT1, ankyrin repeat containing

Synonyms:
CAM, CCM1
Species:
UniProtKB ID:
Gene ID:
  • Human(889) Summary: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
  • Mouse(79264) KRIT1, ankyrin repeat containing
  • Rat(362317) KRIT1, ankyrin repeat containing
  • Zebrafish(321836) KRIT1, ankyrin repeat containing
  • cow(407996) KRIT1, ankyrin repeat containing
  • Horse(100050998) KRIT1, ankyrin repeat containing
  • domestic cat(101083757) KRIT1, ankyrin repeat containing
  • dog(482299) KRIT1, ankyrin repeat containing
  • chicken(420549) KRIT1, ankyrin repeat containing
  • domestic guinea pig(100731041) KRIT1, ankyrin repeat containing
  • naked mole-rat(101725749) KRIT1, ankyrin repeat containing
  • sheep(101110497) KRIT1, ankyrin repeat containing
  • Domestic Rabbit(100344408) KRIT1, ankyrin repeat containing

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