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Merck

KLRC1

killer cell lectin-like receptor subfamily C, member 1

Synonyms:
CD159A, NKG2, NKG2A
Species:
Human KLRC1 (3821), Mouse Klrc1 (16641), Rat Klrc1 (29683), naked mole-rat Klrc1 (101713681), cow KLRC1 (783419), cow KLRC1 (514897)
UniProtKB ID:
P26715
Gene ID:
  • Human(3821) Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(16641) killer cell lectin-like receptor subfamily C, member 1
  • Rat(29683) killer cell lectin-like receptor subfamily C, member 1
  • naked mole-rat(101713681) killer cell lectin-like receptor subfamily C, member 1
  • cow(783419) NKG2A-like
  • cow(514897) killer cell lectin-like receptor subfamily C, member 1

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