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Merck

KDR

kinase insert domain receptor (a type III receptor tyrosine kinase)

Synonyms:
CD309, FLK1, VEGFR, VEGFR2
Species:
Human KDR (3791), Mouse Kdr (16542), Rat Kdr (25589), Goat KDR (100860836), sheep KDR (443087), Domestic Rabbit KDR (100008607), domestic guinea pig Kdr (100726761), naked mole-rat Kdr (101726029), Zebrafish kdr (554230), cow KDR (407170) ...More
UniProtKB ID:
P35968, A2RRS0, B5A925, C5IFA0, O60723, Q14178
Gene ID:
  • Human(3791) Summary: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
  • Mouse(16542) kinase insert domain protein receptor
  • Rat(25589) kinase insert domain receptor
  • Goat(100860836) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • sheep(443087) vascular endothelial growth factor receptor-2
  • Domestic Rabbit(100008607) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • domestic guinea pig(100726761) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • naked mole-rat(101726029) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Zebrafish(554230) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • cow(407170) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Horse(100033959) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • domestic cat(101090260) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • dog(482154) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • chicken(395323) kinase insert domain receptor (a type III receptor tyrosine kinase)
  • Thale Cress(839585) basic helix-loop-helix protein KIDARI

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Antibodies

Product Number
Description
Species Reactivity
Application
GW21181
Anti-VEGFR-2 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
SAB4300067
Anti-phospho-KDR (pTyr1214) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
SAB4504568
Anti-phospho-VEGFR2 (pTyr1214) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
V9134
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse, clone KDR-1, ascites fluid,
Species Reactivity
human
Application
ELISA
immunohistochemistry
V3003
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 (KDR) antibody produced in mouse, clone 260.4, KDR-2, ascites fluid,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
C8863
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human
P2499
PD 173074, ≥96% (HPLC), powder,
Species
mouse, human
PZ0193
Axitinib, ≥98% (HPLC),
Species
human
SML1400
AEE788, ≥98% (HPLC),
Species
human
CDS023028
2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid, ,
Species
human

Proteins

Product Number
Description
Species
V6758
VEGF Receptor-2 (Flk-1, KDR)/Fc Chimera human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
human
K2643
KDR (789-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human