HSPG2
heparan sulfate proteoglycan 2
Synonyms:
HSPG, PLC, PRCAN, SJA, SJS, SJS1
Species:
Human HSPG2 (3339), Mouse Hspg2 (15530), Rat Hspg2 (117511), Zebrafish hspg2 (565429), cow HSPG2 (444872), Horse HSPG2 (100071701), domestic cat HSPG2 (101094520), dog HSPG2 (403440), chicken HSPG2 (429806), sheep HSPG2 (101122677) ...More
UniProtKB ID:
Gene ID:
- Human(3339) Summary: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010]
- Mouse(15530) perlecan (heparan sulfate proteoglycan 2)
- Rat(117511) heparan sulfate proteoglycan 2
- Zebrafish(565429) heparan sulfate proteoglycan 2
- cow(444872) heparan sulfate proteoglycan 2
- Horse(100071701) heparan sulfate proteoglycan 2
- domestic cat(101094520) heparan sulfate proteoglycan 2
- dog(403440) heparan sulfate proteoglycan 2
- chicken(429806) heparan sulfate proteoglycan 2
- sheep(101122677) heparan sulfate proteoglycan 2
- Domestic Rabbit(100340334) heparan sulfate proteoglycan 2
- sheep(100294588) heparan sulfate proteoglycan 2
- domestic guinea pig(100718406) heparan sulfate proteoglycan 2
- naked mole-rat(101700294) heparan sulfate proteoglycan 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HSPG2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot