HARS
histidyl-tRNA synthetase
Synonyms:
HRS, USH3B
Species:
Human HARS (3035), Mouse Hars (15115), Rat Hars (307492), sheep HARS (101120491), Domestic Rabbit HARS (100351394), domestic guinea pig Hars (100729679), naked mole-rat Hars (101712452), Zebrafish hars (447847), chicken HARS (416132), cow HARS (510937) ...More
UniProtKB ID:
Gene ID:
- Human(3035) Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(15115) histidyl-tRNA synthetase
- Rat(307492) histidyl-tRNA synthetase
- sheep(101120491) histidyl-tRNA synthetase
- Domestic Rabbit(100351394) histidyl-tRNA synthetase
- domestic guinea pig(100729679) histidyl-tRNA synthetase
- naked mole-rat(101712452) histidyl-tRNA synthetase
- Zebrafish(447847) histidyl-tRNA synthetase
- chicken(416132) histidyl-tRNA synthetase
- cow(510937) histidyl-tRNA synthetase
- domestic cat(101097371) histidyl-tRNA synthetase
- dog(478034) histidyl-tRNA synthetase
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