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Merck

GZMB

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonyms:
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species:
Human GZMB (3002), Mouse Gzmb (14939), Rat Gzmb (171528), dog GZMB (490630), cow GZMB (508646), cow GZMB (281731), Horse GZMB (100033978), domestic cat GZMB (100127106), domestic guinea pig Gzmb (100736180), naked mole-rat Gzmb (101702156)
UniProtKB ID:
P10144, Q8N1D2, Q9UCC1
Gene ID:
  • Human(3002) Summary: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
  • Mouse(14939) granzyme B
  • Rat(171528) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • dog(490630) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • cow(508646) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • cow(281731) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • Horse(100033978) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • domestic cat(100127106) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • domestic guinea pig(100736180) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
  • naked mole-rat(101702156) granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4700295
Monoclonal Anti-GZMB antibody produced in mouse, clone CLB-GB11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, nonhuman primates
Application
flow cytometry
SAB4501359
Anti-Granzyme B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Kits

Product Number
Description
Species
MAK176
Granzyme B Activity Assay Kit, Sufficient for 100 Fluorometric tests,
Species
mouse, rat, human

Proteins

Product Number
Description
Species
SRP6258
Granzyme B human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Species
human
G9278
Granzyme B from mouse, ≥90% (SDS-PAGE), recombinant, expressed in Pichia pastoris, buffered aqueous solution, ≥10,000 units/mg protein,
Species
mouse
SRP3202
Granzyme B from mouse, recombinant, expressed in Hi-5 Insect cells, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture,
Species
mouse

Small Molecule - Substrate

Product Number
Description
Species
A4188
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin, ≥97% (HPLC), powder,
Species
rat, mouse, human
A6470
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide, ≥97% (HPLC), powder,
Species
rat, mouse, human
A9968
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide, ≥95%,
Species
rat, mouse, human
A6220
N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin, ≥97% (HPLC), powder,
Species
rat, mouse, human