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Merck

GRB10

growth factor receptor-bound protein 10

Synonyms:
GRB-IR, Grb-10, IRBP, MEG1, RSS
Species:
Human GRB10 (2887), Mouse Grb10 (14783), Rat Grb10 (498416), chicken GRB10 (420948), domestic cat GRB10 (101083918), cow GRB10 (407210), Horse GRB10 (100052610), dog GRB10 (607755), domestic guinea pig Grb10 (100733471), naked mole-rat Grb10 (101725734)
UniProtKB ID:
Q13322, A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222
Gene ID:
  • Human(2887) Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
  • Mouse(14783) growth factor receptor bound protein 10
  • Rat(498416) growth factor receptor bound protein 10
  • chicken(420948) growth factor receptor-bound protein 10
  • domestic cat(101083918) growth factor receptor-bound protein 10
  • cow(407210) growth factor receptor-bound protein 10
  • Horse(100052610) growth factor receptor-bound protein 10
  • dog(607755) growth factor receptor-bound protein 10
  • domestic guinea pig(100733471) growth factor receptor-bound protein 10
  • naked mole-rat(101725734) growth factor receptor-bound protein 10
  • sheep(101111275) growth factor receptor-bound protein 10

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