Skip to Content
Merck

FADD

Fas (TNFRSF6)-associated via death domain

Synonyms:
MORT1
Species:
Human FADD (8772), Mouse Fadd (14082), Rat Fadd (266610), Zebrafish fadd (562317), chicken FADD (423146), dog FADD (611694), cow FADD (493720), domestic guinea pig Fadd (100730628), naked mole-rat Fadd (101709972), sheep FADD (101116783)
UniProtKB ID:
Q13158, Q14866, Q6IBR4
Gene ID:
  • Human(8772) Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
  • Mouse(14082) Fas (TNFRSF6)-associated via death domain
  • Rat(266610) Fas (TNFRSF6)-associated via death domain
  • Zebrafish(562317) Fas (tnfrsf6)-associated via death domain
  • chicken(423146) Fas (TNFRSF6)-associated via death domain
  • dog(611694) Fas (TNFRSF6)-associated via death domain
  • cow(493720) Fas (TNFRSF6)-associated via death domain
  • domestic guinea pig(100730628) Fas (TNFRSF6)-associated via death domain
  • naked mole-rat(101709972) Fas (TNFRSF6)-associated via death domain
  • sheep(101116783) Fas (TNFRSF6)-associated via death domain

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
F8053
Anti-FADD antibody, Mouse monoclonal, clone FD19, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
microarray
western blot
SAB4504752
Anti-phospho-FADD (pSer191) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
SRP5180
FADD, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human