DERL1
derlin 1
Synonyms:
DER-1, DER1
Species:
Human DERL1 (79139), Mouse Derl1 (67819), Rat Derl1 (362912), naked mole-rat Derl1 (101722706), domestic guinea pig Derl1 (100727484), Zebrafish derl1 (406753), dog DERL1 (475086), cow DERL1 (404121), domestic cat DERL1 (101100445), chicken DERL1 (420350)
UniProtKB ID:
Gene ID:
- Human(79139) Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
- Mouse(67819) Der1-like domain family, member 1
- Rat(362912) derlin 1
- naked mole-rat(101722706) derlin 1
- domestic guinea pig(100727484) derlin 1
- Zebrafish(406753) Der1-like domain family, member 1
- dog(475086) derlin 1
- cow(404121) derlin 1
- domestic cat(101100445) derlin 1
- chicken(420350) derlin 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Derlin-1 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, canine, hamster, human, monkey, mouse, rat
Application
immunofluorescence
western blot
western blot
Anti-Derlin-1 antibody, Mouse monoclonal, clone Derlin1-1, purified from hybridoma cell culture,
Species Reactivity
bovine, canine, human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot