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Merck

DDR2

discoidin domain receptor tyrosine kinase 2

Synonyms:
MIG20a, NTRKR3, TKT, TYRO10
Species:
Human DDR2 (4921), Mouse Ddr2 (18214), Rat Ddr2 (685781), Zebrafish ddr2 (559428), dog DDR2 (478987), chicken DDR2 (396404), Horse DDR2 (100058300), cow DDR2 (533523), domestic cat DDR2 (101085267), sheep DDR2 (101109754) ...More
UniProtKB ID:
Q16832, Q7Z730
Gene ID:
  • Human(4921) Summary: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Mouse(18214) discoidin domain receptor family, member 2
  • Rat(685781) discoidin domain receptor tyrosine kinase 2
  • Zebrafish(559428) discoidin domain receptor family, member 2
  • dog(478987) discoidin domain receptor tyrosine kinase 2
  • chicken(396404) discoidin domain receptor tyrosine kinase 2
  • Horse(100058300) discoidin domain receptor tyrosine kinase 2
  • cow(533523) discoidin domain receptor tyrosine kinase 2
  • domestic cat(101085267) discoidin domain receptor tyrosine kinase 2
  • sheep(101109754) discoidin domain receptor tyrosine kinase 2
  • naked mole-rat(101712349) discoidin domain receptor tyrosine kinase 2
  • domestic guinea pig(100729537) discoidin domain receptor tyrosine kinase 2

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1305077
MONOCLONAL ANTI-DDR2 antibody produced in mouse, clone 484CT5.5.4, crude ascites, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB5300116
Monoclonal Anti-DDR2 antibody produced in mouse, clone 3B11E4, ascites fluid,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
D7319
DDR2 (467-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human