CTLA4
cytotoxic T-lymphocyte-associated protein 4
Synonyms:
CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species:
Human CTLA4 (1493), Mouse Ctla4 (12477), Rat Ctla4 (63835), Domestic Rabbit CTLA4 (100009412), domestic guinea pig Ctla4 (100725760), naked mole-rat Ctla4 (101722788), chicken CTLA4 (424106), domestic cat CTLA4 (493743), cow CTLA4 (281732), dog CTLA4 (403696)
UniProtKB ID:
Gene ID:
- Human(1493) Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
- Mouse(12477) cytotoxic T-lymphocyte-associated protein 4
- Rat(63835) cytotoxic T-lymphocyte-associated protein 4
- Domestic Rabbit(100009412) cytotoxic T-lymphocyte-associated protein 4
- domestic guinea pig(100725760) cytotoxic T-lymphocyte-associated protein 4
- naked mole-rat(101722788) cytotoxic T-lymphocyte-associated protein 4
- chicken(424106) cytotoxic T-lymphocyte-associated protein 4
- domestic cat(493743) cytotoxic T-lymphocyte-associated protein 4
- cow(281732) cytotoxic T-lymphocyte-associated protein 4
- dog(403696) cytotoxic T-lymphocyte-associated protein 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD152 antibody produced in mouse, ~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
neutralization
western blot
western blot
Anti-CTLA-4 antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse
Application
ELISA
western blot
western blot
Monoclonal Anti-CTLA4 antibody produced in mouse, clone 2F1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
ANTI-IDDM12(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
CD152/Fc Chimera, Non-cytolytic from mouse, ≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized,
Species
mouse
CD152 (human): FC (human) (non-lytic), recombinant, expressed in CHO cells, ≥98% (SDS-PAGE),
Species
human
CD152/Fc Chimera, Cytolytic from mouse, recombinant, expressed in NS.1 cells, buffered aqueous solution,
Species
mouse