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Merck

CSF1R

colony stimulating factor 1 receptor

Synonyms:
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species:
UniProtKB ID:
Gene ID:
  • Human(1436) Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
  • Mouse(12978) colony stimulating factor 1 receptor
  • Rat(307403) colony stimulating factor 1 receptor
  • chicken(396406) colony stimulating factor 1 receptor
  • dog(489188) colony stimulating factor 1 receptor
  • cow(509418) colony stimulating factor 1 receptor
  • Horse(100060422) colony stimulating factor 1 receptor
  • domestic cat(493706) colony stimulating factor 1 receptor
  • domestic guinea pig(100726053) colony stimulating factor 1 receptor
  • naked mole-rat(101719513) colony stimulating factor 1 receptor
  • sheep(101109969) colony stimulating factor 1 receptor

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CSF1R antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
Anti-CSFR antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-CSF-1R antibody, Rabbit monoclonal, clone SP211, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
Monoclonal Anti-CSF1R antibody produced in mouse, clone 1G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay

western blot
Anti-M-CSF Receptor antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Sunitinib malate, ≥98% (HPLC),
Species
human
Pazopanib, ,
Species
human

Proteins

Product Number
Description
Species
FMS (539-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human