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Merck

COX10

cytochrome c oxidase assembly homolog 10 (yeast)

Synonyms:
Species:
Human COX10 (1352), Mouse Cox10 (70383), Rat Cox10 (363617), Zebrafish cox10 (553384), Thale Cress COX10 (819059), cow COX10 (511440), Horse COX10 (100073118), dog COX10 (489515), chicken COX10 (417329), domestic guinea pig Cox10 (100732273)
UniProtKB ID:
Q12887, B2R6U5, O15334, Q969F7
Gene ID:
  • Human(1352) Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
  • Mouse(70383) cytochrome c oxidase assembly protein 10
  • Rat(363617) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • Zebrafish(553384) cytochrome c oxidase assembly homolog 10 (yeast)
  • Thale Cress(819059) protoheme IX farnesyltransferase
  • cow(511440) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • Horse(100073118) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • dog(489515) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • chicken(417329) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
  • domestic guinea pig(100732273) COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2100470
Anti-COX10 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot