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Merck

CACNA1S

calcium channel, voltage-dependent, L type, alpha 1S subunit

Synonyms:
CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP
Species:
UniProtKB ID:
Gene ID:
  • Human(779) Summary: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]
  • Mouse(12292) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • Rat(682930) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • chicken(395985) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • domestic cat(654399) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • cow(100337204) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • Horse(100034092) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • dog(490244) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • sheep(101108767) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • Domestic Rabbit(100009585) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • domestic guinea pig(100734741) calcium channel, voltage-dependent, L type, alpha 1S subunit
  • naked mole-rat(101726232) calcium channel, voltage-dependent, L type, alpha 1S subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin, solid,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Dihydropyridine Receptor (α1 Subunit) antibody produced in mouse, clone 1A, buffered aqueous solution,
Species Reactivity
guinea pig, human, mouse, rabbit, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
Verapamil hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Diltiazem for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Nisoldipine, ≥98% (HPLC),
Species
human
(+)-cis-Diltiazem hydrochloride, ≥99% (HPLC),
Species
human
Verapamil hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human