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Merck

ATP2A2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

Synonyms:
ATP2B, DAR, DD, SERCA2
Species:
Human ATP2A2 (488), Mouse Atp2a2 (11938), Rat Atp2a2 (29693), chicken ATP2A2 (396446), domestic cat ATP2A2 (493691), cow ATP2A2 (540568), Horse ATP2A2 (791242), dog ATP2A2 (403878), naked mole-rat Atp2a2 (101720630), domestic guinea pig Atp2a2 (100174978) ...More
UniProtKB ID:
P16615, A6NDN7, B4DF05, P16614, Q86VJ2
Gene ID:
  • Human(488) Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
  • Mouse(11938) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • Rat(29693) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • chicken(396446) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • domestic cat(493691) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • cow(540568) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • Horse(791242) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • dog(403878) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • naked mole-rat(101720630) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • domestic guinea pig(100174978) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • sheep(101104344) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • Domestic Rabbit(100038308) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  • sheep(100526801) ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

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Antibodies

Product Number
Description
Species Reactivity
Application
S1439
Monoclonal Anti-SERCa2 ATPase antibody produced in mouse, clone IID8,
Species Reactivity
bovine, canine, human, pig, rabbit, rat
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
S1314
Monoclonal Anti-SERCa2 ATPase antibody produced in mouse, clone 2A7-A1, ascites fluid,
Species Reactivity
canine, guinea pig, human, mouse, rabbit, rat
Application
immunoprecipitation (IP)
western blot