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A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction.

Journal of the American Chemical Society (2005-09-22)
Cyril Bressy, Dino Alberico, Mark Lautens
RESUMEN

A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.

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Sigma-Aldrich
(2-Bromoethoxy)-tert-butyldimethylsilane, 99%