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Key Documents

PRS3897

Sigma-Aldrich

Anti-TRPC6 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Htrp6, Anti-Short transient receptor potential channel 6, Anti-Transient receptor potential cation channel, subfamily C, member 6

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About This Item

MDL number:
MFCD02686669
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 100-102 kDa

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q9Y210

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRPC6(7225)

Immunogen

a 14 amino acid peptide from near the carboxy-terminus of human TRPC6.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3897.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Related product

Referencia del producto
Descripción
Precios

SBP3897

TRPC6 (AB1) Blocking Peptide for PRS3897

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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The mechanisms by which NaCl raises blood pressure (BP) in hypertension are unresolved, but much evidence indicates that endogenous ouabain is involved. In rodents, arterial smooth muscle cell (ASMC) Na(+) pumps with an α(2)-catalytic subunit (ouabain EC(50) ≤1.0 nM) are
Kimberly A Smith et al.
American journal of respiratory cell and molecular biology, 53(3), 355-367 (2015-01-09)
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). We have previously shown that Notch3 is up-regulated in HPH

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