P6500

Pentylenetetrazole

≥99% (GC), powder, CNS stimulant

• Sinónimos: α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
• Fórmula empírica (notación de Hill): C₆H₁₀N₄
• Número de CAS: 54-95-5
• Peso molecular: 138.17
• EC Number: 200-219-3
• MDL number: MFCD00005939
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278643
• NACRES: NA.77

Propiedades

• product name: Pentylenetetrazole,
• form: powder
• bp: 194 °C/12 mmHg (lit.)
• mp: 59-61 °C (lit.)
• storage temp.: −20°C
• SMILES string: C1CCc2nnnn2CC1
• InChI: 1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
• InChI key: CWRVKFFCRWGWCS-UHFFFAOYSA-N

Descripción

General description

Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier.

Application

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Biochem/physiol Actions

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges