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71230

Sigma-Aldrich

Timerosal

97.0-101.0% (on dried substance, T)

Sinónimos:

Etilmercuritiosalicilato de sodio, Mercuri-([o-carboxifenil]tio)etil sodium salt, Ácido 2-(etilmercuriomercapto)benzoico sodium salt, Ácido etilmercuritiosalicílico sodium salt

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About This Item

Fórmula lineal:
2-(C2H5HgS)C6H4CO2Na
Número de CAS:
54-64-8
Peso molecular:
404.81
Beilstein/REAXYS Number:
8169555
EC Number:
200-210-4
MDL number:
MFCD00013062
UNSPSC Code:
51473202
PubChem Substance ID:
329763125
NACRES:
NA.21

Quality Level

200

assay

97.0-101.0% (on dried substance, T)

form

powder

mp

234-237 °C (dec.) (lit.)

mode of action

enzyme | inhibits

SMILES string

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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Biochem/physiol Actions

El timerosal es un reactivo oxidante de sulfhidrilo (tiol) capaz de inhibir una amplia variedad de enzimas dependientes del sulfhidrilo y proteínas como la metionina sintasa dependiente de PI3-cinasa, receptores de transporte de glutamato y las ATPasas dependientes de Na++K+.

Analysis Note

Solubility (EP/BP) Freely soluble in water, sparingly soluble or soluble in ethanol (96%), practically insoluble in ether and methylene cholride.

Other Notes

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

target_organs

Kidney

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
089M4021V
029M4106V
029M4106V
048M4034V
127M4144V

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Ildiko R Dunay et al.
Antimicrobial agents and chemotherapy, 48(12), 4848-4854 (2004-11-25)
Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is
John M Feller et al.
The Journal of clinical endocrinology and metabolism, 93(9), 3560-3567 (2008-06-12)
Hyperinsulinism with islet cell hyperplasia is a frequent complication, of unknown cause, in hemolytic disease of the newborn, occurring in Rh(D)-positive infants of Rh-isoimmunized Rh(D)-negative mothers, but not in infants with other hemolytic disorders. We investigated the possibility that trans-placentally
Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research
Dorota Mrozek-Budzyn et al.
Neurotoxicology and teratology, 34(6), 592-597 (2012-10-17)
Despite the common use of Thimerosal as a preservative in childhood vaccines since the 1930s, there are not many studies on ethylmercury toxicokinetics and toxicodynamics in infants. The knowledge of ethylmercury's potential adverse effects is derived mostly from parallel methylmercury
Alicia Bazzano et al.
American journal on intellectual and developmental disabilities, 117(3), 233-242 (2012-06-22)
Although the assertion of a link between vaccines and autism has been scientifically rejected, the theory continues to be popular and may influence the attitudes of parents of children with autism spectrum disorders. The authors sought to assess how often
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