218728

Caspase-9 Inhibitor III

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinónimos: Caspase-9 Inhibitor III, Ac-LEHD-CMK
• Fórmula empírica (notación de Hill): C₂₄H₃₅ClN₆O₉
• Número de CAS: 403848-57-7
• Peso molecular: 587.02
• UNSPSC Code: 12352200
• NACRES: NA.54

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white
• solubility: water: 1 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).

A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 70 nM against caspase-9

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Leu-Glu-His-Asp-CMK

Other Notes

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable