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L1002

Sigma-Aldrich

L-Leucine methyl ester hydrochloride

98%, for peptide synthesis

Sinónimos:

(S)-2-Amino-4-methylpentanoic acid methyl ester hydrochloride, L-Leu-OMe·HCl

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About This Item

Fórmula lineal:
(CH3)2CHCH2CH(NH2)COOCH3 · HCl
Número de CAS:
7517-19-3
Peso molecular:
181.66
Beilstein/REAXYS Number:
3595133
EC Number:
231-375-0
MDL number:
MFCD00012494
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24896269
NACRES:
NA.22

product name

L-Leucine methyl ester hydrochloride, 98%

assay

98%

form

powder or crystals

optical activity

[α]22/D +13°, c = 2 in H2O

reaction suitability

reaction type: solution phase peptide synthesis

color

white

mp

151-153 °C (lit.)

application(s)

peptide synthesis

SMILES string

Cl[H].COC(=O)[C@@H](N)CC(C)C

InChI

1S/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/m0./s1

InChI key

DODCBMODXGJOKD-RGMNGODLSA-N

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Stephanie M Krasnow et al.
Journal of neuroinflammation, 14(1), 133-133 (2017-07-03)
During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in the brain are the proximal targets for IL-1β with respect to the
Gautam K Gandhi et al.
ASN neuro, 2(2), e00030-e00030 (2010-04-17)
Sensory and cognitive impairments have been documented in diabetic humans and animals, but the pathophysiology of diabetes in the central nervous system is poorly understood. Because a high glucose level disrupts gap junctional communication in various cell types and astrocytes
Kenneth W Kross et al.
Acta oto-laryngologica, 127(5), 532-539 (2007-04-25)
Conclusion. Tumour-associated macrophages (TAMs) in head and neck squamous cell carcinomas (HNSCCs) secrete interleukin 6 (IL-6) and monocyte chemotactic protein (MCP-1) that can be down-regulated by L-leucine-methylester (LLME); however, there is no qualitative difference between function of TAMs and tissue
D R Brown et al.
Nature, 380(6572), 345-347 (1996-03-28)
The prion protein PrPc is a glycoprotein of unknown function normally found in neurons and glia. It is involved in diseases such as bovine spongiform encephalopathy (BSE), scrapie and Creutzfeldt-Jakob disease. PrPSc, an altered isoform of PrPC that is associated
Mary E Hamby et al.
Journal of neuroscience methods, 150(1), 128-137 (2005-08-18)
Cultures of astrocytes can be readily established and are widely used to study the biological functions of these glial cells in isolation. Unfortunately, contamination by microglia can confound results from such studies. Herein, a simple and highly effective modification of
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