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Documentos

857858

Sigma-Aldrich

5-Iodouracil

98%

Sinónimos:

2,4-Dihydroxy-5-iodopyrimidine

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About This Item

Fórmula empírica (notación de Hill):
C4H3IN2O2
Número de CAS:
696-07-1
Peso molecular:
237.98
EC Number:
211-788-2
MDL number:
MFCD00006020
UNSPSC Code:
12352100
PubChem Substance ID:
24888454
NACRES:
NA.22

Quality Level

100

assay

98%

form

powder

mp

274-276 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

IC1=CNC(=O)NC1=O

InChI

1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

KSNXJLQDQOIRIP-UHFFFAOYSA-N

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Categorías relacionadas

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

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Xiaorong Sun et al.
Oncotarget, 6(33), 34732-34744 (2015-09-30)
Bortezomib, a novel proteasome inhibitor, has been approved for treating multiple myeloma and mantle cell lymphoma and studied pre-clinically and clinically for solid tumors. Preferential cytotoxicity of bortezomib was found toward hypoxic tumor cells and endothelial cells in vitro. The
Takanori Oyoshi et al.
Journal of the American Chemical Society, 125(6), 1526-1531 (2003-02-06)
DNA local conformations are thought to play an important biological role in processes such as gene expression by altering DNA-protein interactions. Although left-handed Z-form DNA is one of the best-characterized and significant local structures of DNA, having been extensively investigated
S Sastry et al.
Biochemistry, 38(16), 4972-4981 (1999-04-23)
Transcription is the fundamental process by which RNA is synthesized by RNA polymerases on double-stranded DNA templates. One structurally simple RNA polymerase is encoded by bacteriophage T7. T7 RNA polymerase is an excellent candidate for studying structural aspects of transcription
J D Robertson et al.
Pharmaceutical research, 9(11), 1410-1414 (1992-11-01)
X-ray fluorescence (XRF) has been used to determine in vivo the percutaneous absorption of 5-iodouracil (5IU) in dimethyl sulfoxide (DMSO) on female Sprague-Dawley rats. An average absorption rate constant of 122 +/- 34 micrograms/cm2-hr was obtained from the XRF measurements
A Jeltsch et al.
Journal of molecular biology, 285(3), 1121-1130 (1999-01-27)
DNA methyltransferases flip their target base out of the DNA helix. Here, we have investigated base flipping by wild-type EcoRV DNA methyltransferase (M.EcoRV) and five M.EcoRV variants (D193A, Y196A, S229A, W231R and Y258A). These variants bind to DNA and S-adenosylmethionine
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