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Merck

HLA-C

major histocompatibility complex, class I, C

Sinónimos:
D6S204, HLA-JY3, HLC-C, PSORS1
Especie:
ID UniProtKB:
ID del gen:
  • Human(3107) Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
Anti-HLA-C Antibody, clone DT9, clone DT9, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
immunoprecipitation (IP)
Anti-HLA-C antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
Anti-HLA-C antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, pig, rabbit
Aplicación
western blot
Monoclonal Anti-HLA Class I Antigen antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human, monkey
Aplicación
flow cytometry
immunofluorescence

immunoprecipitation (IP)
Anticuerpo anti-antígenos HLA de Clase I, clon W6/32, clone W6/32, from mouse,
Reactividad de especies
human
Aplicación
affinity binding assay
affinity chromatography

flow cytometry

immunohistochemistry

immunoprecipitation (IP)

neutralization