Saltar al contenido
MilliporeSigma

GREM1

gremlin 1, DAN family BMP antagonist

Sinónimos:
CKTSF1B1, DAND2, DRM, GREMLIN, IHG-2
Especie:
ID UniProtKB:
ID del gen:
  • Human(26585) Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(23892) gremlin 1
  • Rat(50566) gremlin 1
  • chicken(395826) gremlin 1
  • cow(539079) gremlin 1
  • domestic cat(101096735) gremlin 1
  • dog(487475) gremlin 1
  • Goat(100860969) gremlin 1
  • sheep(101102396) gremlin 1
  • domestic guinea pig(100730568) gremlin 1, DAN family BMP antagonist
  • naked mole-rat(101720734) gremlin 1, DAN family BMP antagonist

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Referencia del producto
Descripción
Especie
Mouse Gremlin-1 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Especie
mouse

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Gremlin-1 Antibody, clone 2H1.1, clone 2H1.1, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
ANTI-GREMLIN (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
Monoclonal Anti-GREM1 antibody produced in mouse, clone 2C9, ascites fluid, solution,
Reactividad de especies
human
Aplicación
ELISA
Anti-Grem1 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Aplicación
western blot
Anti-Grem1 (C-terminal) antibody produced in rabbit biotin conjugated, affinity isolated antibody,
Reactividad de especies
bovine, canine, goat, guinea pig, horse, human, mouse, rabbit, zebrafish
Aplicación

Proteins

Referencia del producto
Descripción
Especie
GREMLIN-1 human, recombinant, expressed in CHO cells, ≥90% (SDS-PAGE), ≥90% (HPLC),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human GREM1,
Especie
human
MISSION® esiRNA, targeting mouse Grem1,
Especie
mouse