FAS
Fas cell surface death receptor
Sinónimos:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Especie:
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), Zebrafish fas (768248), fruit fly fas (36521), domestic cat FAS (493881), cow FAS (282488), Horse FAS (100071639), dog FAS (486469), chicken FAS (395274) ...Más
ID UniProtKB:
ID del gen:
- Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- Mouse(14102) Fas (TNF receptor superfamily member 6)
- Rat(246097) Fas cell surface death receptor
- Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
- fruit fly(36521) faint sausage
- domestic cat(493881) Fas (TNF receptor superfamily, member 6)
- cow(282488) Fas (TNF receptor superfamily, member 6)
- Horse(100071639) Fas (TNF receptor superfamily, member 6)
- dog(486469) Fas (TNF receptor superfamily, member 6)
- chicken(395274) Fas (TNF receptor superfamily, member 6)
- domestic guinea pig(100726403) Fas cell surface death receptor
- naked mole-rat(101704746) Fas cell surface death receptor
- sheep(100144426) Fas (TNF receptor superfamily, member 6)
- Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
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ELISA
Referencia del producto
Descripción
Especie
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-Fas (humano, neutralizante), clon ZB4, clone ZB4, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
neutralization
western blot
neutralization
western blot
Anticuerpo anti-Fas (humano, activador), clon CH11, clone CH11, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-FAS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Fas Antibody, clone SM1/1, clone SM1/1, Chemicon®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
Anti-Fas Ligand Antibody, Chemicon®, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Proteins
Referencia del producto
Descripción
Especie
Fas Intracellular Domain human, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution,
Especie
human
Fas/Fc Chimera from mouse, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture,
Especie
mouse
FAS Receptor human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Especie
human