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Merck

F8

coagulation factor VIII, procoagulant component

Sinónimos:
AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Especie:
Human F8 (2157), Mouse F8 (14069), Rat F8 (302470), Zebrafish f8 (100302404), chicken F8 (422199), cow F8 (100271720), domestic cat F8 (101092751), dog F8 (403875), sheep F8 (100359363), Domestic Rabbit F8 (100303761) ...Más
ID UniProtKB:
P00451, Q14286, Q5HY69
ID del gen:
  • Human(2157) Summary: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
  • Mouse(14069) coagulation factor VIII
  • Rat(302470) coagulation factor VIII, procoagulant component
  • Zebrafish(100302404) coagulation factor VIII, procoagulant component
  • chicken(422199) coagulation factor VIII, procoagulant component
  • cow(100271720) coagulation factor VIII, procoagulant component
  • domestic cat(101092751) coagulation factor VIII, procoagulant component
  • dog(403875) coagulation factor VIII, procoagulant component
  • sheep(100359363) coagulation factor VIII, procoagulant component
  • Domestic Rabbit(100303761) coagulation factor VIII, procoagulant component
  • domestic guinea pig(100720831) coagulation factor VIII, procoagulant component
  • naked mole-rat(101725450) coagulation factor VIII, procoagulant component

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB4500827
Anti-Factor VIII antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
ELISA
western blot
SAB1410356
Anti-F8 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reactividad de especies
human
Aplicación
western blot
SAB5300300
Monoclonal Anti-F8 antibody produced in mouse, clone 5E9B2, ascites fluid,
Reactividad de especies
human
Aplicación
ELISA
western blot
05-871
Anti-Factor VIII Antibody, clone GMA-012, clone GMA-012, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
ELISA
western blot
05-861
Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022, clone GMA-022, Upstate®, from mouse,
Reactividad de especies
human
Aplicación
western blot

esiRNA

Referencia del producto
Descripción
Especie
EHU158241
MISSION® esiRNA, targeting human F8,
Especie
human