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Merck

EGLN1

egl-9 family hypoxia-inducible factor 1

Sinónimos:
C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6
Especie:
Human EGLN1 (54583), Mouse Egln1 (112405), Rat Egln1 (308913), Zebrafish egln1 (436868), cow EGLN1 (534075), domestic cat EGLN1 (101089964), dog EGLN1 (488971), sheep EGLN1 (101114163), naked mole-rat Egln1 (101709882), domestic guinea pig Egln1 (100726309)
ID UniProtKB:
Q9GZT9, Q8N3M8, Q9BZS8, Q9BZT0
ID del gen:
  • Human(54583) Summary: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
  • Mouse(112405) EGL nine homolog 1 (C. elegans)
  • Rat(308913) EGL nine homolog 1 (C. elegans)
  • Zebrafish(436868) egl nine homolog 1 (C. elegans)
  • cow(534075) egl nine homolog 1 (C. elegans)
  • domestic cat(101089964) egl nine homolog 1 (C. elegans)
  • dog(488971) egl nine homolog 1 (C. elegans)
  • sheep(101114163) egl nine homolog 1 (C. elegans)
  • naked mole-rat(101709882) egl nine homolog 1 (C. elegans)
  • domestic guinea pig(100726309) egl nine homolog 1 (C. elegans)

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
ZRB1993
Anti-PHD2/EGLN1 Antibody, clone 1B12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
HPA022129
Anti-EGLN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
MABC1612
Anti-phospho-PHD2 (Ser 125) Antibody, clone 4, ,
Reactividad de especies
human
Aplicación
SAB5700099
Anti-EGLN1 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
MABC1612M
Anti-phospho-PHD2 (Ser 125) Antibody, clone 4, clone 4, from mouse,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Descripción
Especie
EHU088381
MISSION® esiRNA, targeting human EGLN1,
Especie
human