DCX
doublecortin
Sinónimos:
DBCN, DC, LISX, SCLH, XLIS
Especie:
Human DCX (1641), Mouse Dcx (13193), Rat Dcx (84394), sheep DCX (101109861), naked mole-rat Dcx (101711611), domestic guinea pig Dcx (100713827), chicken DCX (374242), domestic cat DCX (494212), cow DCX (787968), Horse DCX (100058909)
ID UniProtKB:
ID del gen:
- Human(1641) Summary: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
- Mouse(13193) doublecortin
- Rat(84394) doublecortin
- sheep(101109861) doublecortin
- naked mole-rat(101711611) doublecortin
- domestic guinea pig(100713827) doublecortin
- chicken(374242) doublecortin
- domestic cat(494212) doublecortin
- cow(787968) doublecortin
- Horse(100058909) doublecortin
- dog(612950) doublecortin
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-DCX, clon 2G5, clone 2G5, from mouse,
Reactividad de especies
human, mouse
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-DCX (AB1) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-DCX antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-DCX antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-Dcx antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
esiRNA
Referencia del producto
Descripción
Especie