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Hybrid localized surface plasmon resonance and quartz crystal microbalance sensor for label free biosensing.

Biosensors & bioelectronics (2017-08-30)
Danni Hao, Chunxiao Hu, James Grant, Andrew Glidle, David R S Cumming
ABSTRACT

We report on the design and fabrication of a hybrid sensor that integrates transmission-mode localized surface plasmonic resonance (LSPR) into a quartz crystal microbalance (QCM) for studying biochemical surface reactions. The coupling of LSPR nanostructures and a QCM allows optical spectra and QCM resonant frequency shifts to be recorded simultaneously and analyzed in real time for a given surface adsorption process. This integration simplifies the conventional combination of SPR and QCM and has the potential to be miniaturized for application in point-of-care (POC) diagnostics. The influence of antibody-antigen recognition effect on both the QCM and LSPR has been analyzed and discussed.

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Sigma-Aldrich
N-Hydroxysulfosuccinimide sodium salt, ≥98% (HPLC)