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Synthesis and In Vitro Performance of Polypyrrole-Coated Iron-Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging.

Nanoscale research letters (2017-10-20)
Thi Tuong Vy Phan, Nhat Quang Bui, Madhappan Santha Moorthy, Kang Dae Lee, Junghwan Oh
ABSTRACT

Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron-platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI. In vitro investigation experimentally demonstrated the effectiveness of FePt@PPy NPs in killing cancer cells with NIR laser irradiation. Moreover, the phantom test of PAI used in conjunction with FePt@PPy NPs showed a strong photoacoustic signal. Thus, the novel FePt@PPy NPs could be considered as promising multifunctional nanoparticles for further applications of photo-based diagnosis and treatment.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1-Octadecene, technical grade, 90%
Sigma-Aldrich
Platinum(II) acetylacetonate, 97%
Sigma-Aldrich
Dioctyl ether, 99%
Sigma-Aldrich
1,2-Hexadecanediol, technical grade, 90%