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  • Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.

Human molecular genetics (2016-04-30)
Johanna I Busch, Travis L Unger, Nimansha Jain, R Tyler Skrinak, Rakshita A Charan, Alice S Chen-Plotkin
ABSTRACT

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is an important cause of dementia in individuals under age 65. Common variants in the TMEM106B gene were previously discovered by genome-wide association to confer genetic risk for FTLD-TDP (p = 1 × 10

MATERIALS
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Brand
Product Description

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Cycloheximide, Biotechnology Performance Certified
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Anti-C9orf72 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
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MISSION® esiRNA, targeting human C9ORF72