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Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line.

Toxicology in vitro : an international journal published in association with BIBRA (2016-10-19)
Bedia Begüm Karakoçak, Ramesh Raliya, Josh T Davis, Sanmathi Chavalmane, Wei-Ning Wang, Nathan Ravi, Pratim Biswas
ABSTRACT

Gold nanoparticles (Au NPs) have been tested as targeted delivery agents because of their high chemical stability and surface plasmon properties. Here, we investigated the biocompatibility of Au spheres (5-, 10-, 20-, 30-, 50-. and 100-nm), cubes (50-nm), and rods (10×90nm) on a retinal pigment epithelial (ARPE-19) cell line. The lethal dose for killing 50% of the cells (LD

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(3-Mercaptopropyl)trimethoxysilane, 95%