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Catalytic selective deuteration of halo(hetero)arenes.

Organic & biomolecular chemistry (2016-02-24)
Manojkumar Janni, S Peruncheralathan
ABSTRACT

Deuterium labeled aromatic and heteroaromatic compounds are synthesized in good to excellent yields with >98% deuterium purity via palladium catalyzed deuterodehalogenation reaction using commercially available and inexpensive reagents. Selective deuteration of bromoaniline is also demonstrated without H/D exchange in an amino N-H group.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tri(o-tolyl)phosphine, 97%
Sigma-Aldrich
Poly(dimethylsiloxane), viscosity 1.0 cSt (25 °C)